News

Jul 2021 Publication: The histone chaperone HIR maintains chromatin states to control nitrogen assimilation and fungal virulence. Jenull S, Mair T, Tscherner M, Penninger P, Zwolanek F, Silao FS, de San Vicente KM, Riedelberger M, Bandari NC, Shivarathri R, Petryshyn A, Chauhan N, Zacchi LF, -Landmann SL, Ljungdahl PO, Kuchler K. Cell Rep. 2021 Jul 20;36(3):109406. doi: 10.1016/j.celrep.2021.109406.

Nov 2016 Publication: The Paralogous Histone Deacetylases Rpd3 and Rpd31 Play Opposing Roles in Regulating the White-Opaque Switch in the Fungal Pathogen Candida albicans. Xie J, Jenull S, Tscherner M, Kuchler K. MBio. 2016 Nov 15;7(6). pii: e01807-16. doi: 10.1128/mBio.01807-16.

Nov 2016 Publication: Fungal KATs/KDACs: A New Highway to Better Antifungal Drugs? Kuchler K, Jenull S, Shivarathri R, Chauhan N. PLoS Pathog. 2016 Nov 10;12(11):e1005938. doi: 10.1371/journal.ppat.1005938. No abstract available.

Nov 2016 Publication: Immunological Identification of Fungal Species. Nogueira F, Istel F, Pereira L, Tscherner M, Kuchler K. Methods Mol Biol. 2017;1508:339-359.

Aug 2016 Publication: Inhibition of CBLB protects from lethal Candida albicans sepsis. Wirnsberger G, Zwolanek F, Asaoka T, Kozieradzki I, Tortola L, Wimmer RA, Kavirayani A, Fresser F, Baier G, Langdon WY, Ikeda F, Kuchler K, Penninger JM. Nat Med. 2016 Aug;22(8):915-23. doi: 10.1038/nm.4134.

Oct 2015 Publication: The Candida albicans Histone Acetyltransferase Hat1 Regulates Stress Resistance and Virulence via Distinct Chromatin Assembly Pathways.Tscherner M, Zwolanek F, Jenull S, Sedlazeck FJ, Petryshyn A, Frohner IE, Mavrianos J, Chauhan N, von Haeseler A, Kuchler K. PLoS Pathog. 2015 Oct 16;11(10):e1005218. doi: 10.1371/journal.ppat.1005218.

Jul 2015 Publication: Large-scale Phenotypic Profiling of Gene Deletion Mutants in Candida glabrata. Istel F, Schwarzmüller T, Tscherner M, Kuchler K.Bio Protoc. 2015 Jul 20;5(14). pii: e1530.

Jul 2015 Publication: Genetic Transformation of Candida glabrata by Heat Shock. Istel F, Schwarzmüller T, Tscherner M, Kuchler K.Bio Protoc. 2015 Jul 20;5(14). pii: e1529

Jul 2015 Publication: Genetic Transformation of Candida glabrata by Electroporation. Istel F, Schwarzmüller T, Tscherner M, Kuchler K. Bio Protoc. 2015 Jul 20;5(14). pii: e1528.

Dec 2014 Publication: The non-receptor tyrosine kinase Tec controls assembly and activity of the noncanonical caspase-8 inflammasome. Zwolanek F, Riedelberger M, Stolz V, Jenull S, Istel F, Köprülü AD, Ellmeier W, Kuchler K. PLoS Pathog. 2014 Dec 4;10(12):e1004525. doi: 10.1371/journal.ppat.1004525.

Jun 2014 Publication: Systematic phenotyping of a large-scale Candida glabrata deletion collection reveals novel antifungal tolerance genes. Schwarzmüller T, Ma B, Hiller E, Istel F, Tscherner M, Brunke S, Ames L, Firon A, Green B, Cabral V, Marcet-Houben M, Jacobsen ID, Quintin J, Seider K, Frohner I, Glaser W, Jungwirth H, Bachellier-Bassi S, Chauvel M, Zeidler U, Ferrandon D, Gabaldón T, Hube B, d'Enfert C, Rupp S, Cormack B, Haynes K, Kuchler K. PLoS Pathog. 2014 Jun 19;10(6):e1004211. doi: 10.1371/journal.ppat.1004211.

Dec 2012 Publication: A histone deacetylase adjusts transcription kinetics at coding sequences during Candida albicans morphogenesis.Hnisz D, Bardet AF, Nobile CJ, Petryshyn A, Glaser W, Schöck U, Stark A, Kuchler K. PLoS Genet. 2012;8(12):e1003118. doi: 10.1371/journal.pgen.1003118

Dec 2012 Publication:The histone acetyltransferase Hat1 facilitates DNA damage repair and morphogenesis in Candida albicans. Tscherner M, Stappler E, Hnisz D, Kuchler K. Mol Microbiol. 2012 Dec;86(5):1197-214. doi: 10.1111/mmi.12051.

Nov 2012 Publication:Fungal pathogens-a sweet and sour treat for toll-like receptors. Bourgeois C, Kuchler K. Front Cell Infect Microbiol. 2012 Nov 22;2:142. doi: 10.3389/fcimb.2012.00142. Review.

Jul 2012 Publication:Type I interferons promote fatal immunopathology by regulating inflammatory monocytes and neutrophils during Candida infections. Majer O, Bourgeois C, Zwolanek F, Lassnig C, Kerjaschki D, Mack M, Müller M, Kuchler K.. PLoS Pathog. 2012;8(7):e1002811. doi: 10.1371/journal.ppat.1002811. Epub 2012 Jul 26.

Mar 2012 Publication: An Interspecies Regulatory Network Inferred from Simultaneous RNA-seq of Candida albicans Invading Innate Immune Cells. Tierney L, Linde J, Müller S, Brunke S, Molina JC, Hube B, Schöck U, Guthke R, Kuchler K. Front Microbiol. 2012 Mar 12;3:85. doi: 10.3389/fmicb.2012.00085.

Dec 2011 Publication: Efg1 Controls caspofungin-induced cell aggregation of Candida albicans through the adhesin Als1. Gregori C, Glaser W, Frohner IE, Reinoso-Martín C, Rupp S, Schüller C, Kuchler K. Eukaryot Cell. 2011 Dec;10(12):1694-704. Epub 2011 Oct 28.

Sep 2011 Publication: The ABC of ABCs: multidrug resistance and genetic diseases. Kuchler K. FEBS J. 2011 Sep;278(18):3189. doi: 10.1111/j.1742-4658.2011.08234.x. Epub 2011 Aug 1.

Apr 2011 Publication: Targeting chromatin in fungal pathogens as a novel therapeutic strategy: histone modification gets infectious. Hnisz D, Tscherner M, Kuchler K. Epigenomics. 2011 Apr;3(2):129-32.

Apr 2011 Publication: Morphological and molecular genetic analysis of epigenetic switching of the human fungal pathogen Candida albicans. Hnisz D, Tscherner M, Kuchler K. Methods Mol Biol. 2011;734:303-15.

Mar 2011 Publication: Conventional dendritic cells mount a type I IFN response against Candida spp. requiring novel phagosomal TLR7-mediated IFN-β signaling. Bourgeois C, Majer O, Frohner IE, Lesiak-Markowicz I, Hildering KS, Glaser W, Stockinger S, Decker T, Akira S, Müller M, Kuchler K. J Immunol. 2011 Mar 1;186(5):3104-12.

May 2010 Publication: Hnisz D, Majer O, Frohner IE, Komnenovic V, Kuchler K (2010) The Set3/Hos2 Histone Deacetylase Complex Attenuates cAMP/PKA Signaling to Regulate Morphogenesis and Virulence of Candida albicans. PLoS Pathog 6(5): e1000889. doi:10.1371/journal.ppat.1000889

Oct 2009 Publication: Hnisz, D., Schwarzmüller, T., and Kuchler, K. (2009). Transcriptional loops meet chromatin: a dual-layer network controls white-opaque switching in Candida albicans. Mol. Microbiol 74, 1-15.

Aug 2009 The FEBS-ABC2010 Website is now online.

Jan 2009 Publication: Frohner, I. E., Bourgeois, C., Yatsyk, K., Majer, O., and Kuchler, K. (2009). Candida albicans cell surface superoxide dismutases degrade host-derived reactive oxygen species to escape innate immune surveillance. Mol. Microbiol 71, 240-252.  

Dec 2008 Publication: Bourgeois, C., Majer, O., Frohner, I., and Kuchler, K. (2009). In vitro systems for studying the interaction of fungal pathogens with primary cells from the mammalian innate immune system. Methods Mol. Biol 470, 125-139.

Sep 2008 Publication: Gregori, C., Schüller, C., Frohner, I. E., Ammerer, G., and Kuchler, K. (2008). Weak organic acids trigger conformational changes of the yeast transcription factor War1 in vivo to elicit stress adaptation. J. Biol. Chem 283, 25752-25764.